MOFO= Mother F%$ker
Its really just a slang joke generally said in jest.
It's a sure bet we won't hear anything about Hillery's colorful language from the breathless MSM.
Gee, and here I was thinkin' it was a subwoofer :)
Sheesh... He doesn't even know to use the TRUE acronym for that phrase? AMF!
I imagine that it is a term similar to the use of "Geez" to avoid avoid saying "Jesus".