Hebrew U Researcher Finds Hashish Derivatives Effective In Halting Cancer In Lab Tests

GLOBES Online ^ | June 15, 2005

[Wolfie]

Hebrew U Researcher Finds Hashish Derivatives Effective In Halting Cancer In Lab Tests

Derivatives of the cannabis plant (hashish) have been shown by a Hebrew University of Jerusalem Ph.D. student to be effective in arresting cancerous growths in laboratory and animal tests.

For her work, Natalya Kogan was one of the winners of a Kaye Innovation Award, presented today during the 68th meeting of the Hebrew University Board of governors.

Kogan is supervised by Prof. Raphael Mechoulam at the Hebrew University School of Pharmacy. Mechoulam is best known for his work in the field of the constituents of cannabis and the endogenous cannabinoids found in the brain. Mechoulam's cannabis-based patents were licensed for drug development by Pharmos (Nasdaq: PARS).

Kogan, in collaboration with Prof. Michael Schlesinger at the Hebrew University-Hadassah Medical School and Prof. Ester Priel at Ben-Gurion University of the Negev, has developed new compounds known as quinonoid cannabinoids that parallel in their activity a group of anti-cancer drugs, the best known of which is daunomycin.

However, while daunomycin is toxic to the heart, Kogan, with Dr. Ronen Beeri and Dr. Gergana Marincheva of Hadassah University Hospital, Ein Kerem, found that the quinonoid cannabinoids are much less cardiotoxic. The development of quinonoid compounds that display anticancer activity, but are less toxic, is a major therapeutic goal. At present, Kogan is continuing to investigate the mechanism of action of these promising compounds.

All of the compounds synthesized by Kogan inhibited cancer cell growth in cell culture, and one of them was found to markedly reduce the volume of tumors in animal studies The cannabinoid quinones were found to act through a rather unique pathway of cancer cell destruction -- by specific inhibition of topoisomerase II, an enzyme that participates in cell replication. Most of the known anti-cancer drugs are less selective, acting by numerous mechanisms.

Additionally, the most active compound in the series developed by Kogan, as well as some other cannabinoids, were found by Kogan and Prof. Ruth Galilli of the Hebrew University to have anti-angiogenic properties. Angiogenesis, the process of new blood vessel formation, is crucial for tumor growth, and much effort has been invested by researchers in the development of compounds with anti-angiogenic activity.

Since the compounds developed by Kogan have anti-cancer properties and are more selective and potent than standard chemotherapy drugs, they have a high potential for use in new anti-cancer drugs

Kogan was born in 1980 in Cherkassy, Ukraine, and immigrated to Israel in 1995. She earned B.Pharm and M.Sc degrees at the Hebrew University School of Pharmacy and graduated with excellence.

She has received numerous prior awards: the Wolf Prize for junior investigators (2005); the Keren Kayemet prize (2005); and a Best Poster Award at the 2004 Symposium of the International Cannabinoids Research Society. Her Ph.D. work is supported by a personal award (for high grades and research achievements) from the Canadian Friends of the Hebrew University.

The Kaye Innovation Awards at the Hebrew University have been awarded annuallysince 1994. Isaac Kaye of England, a prominent industrialist in the pharmaceutical industry, established the awards to encourage faculty, staff, and students of the university to develop innovative methods and inventions with good commercial potential which have benefited or will benefit the university and society.

[thoughtomator]

That's nice, but it's already been made eminently clear that it doesn't matter how many people have to die to satisfy the blood lust of the Drug War.

[Wolfie]

Don't be so pessimistic. Its only people in this country that have to die. The rest of the world gets it.

[Sir Gawain]

Lies lies lies! I'm not listening! {closes ears} la la la I can't hear you!

[mcg1969]

Woo-hoo! I'm a gonna be cancer free!

[Wolfie]

They weren't listening in 1974 either. In fact, they went out of their way to quash the research.

Pot Shrinks Tumors; Government Knew in '74

[robertpaulsen]

"Pot Shrinks Tumors; Government Knew in '74"

"100 MPG Carburetor; Government Hides Plans"

[aimhigh]

Killing cancer in lab tests is easy, and has been done many times. Getting repeated results in humans is the real test.

[Nathan Zachary]

It's got nothing to do with the war on drugs.

And don't jump to the conclusion that smoking hash will cure cancer either. Read carefully, She synthesized compounds from hashish. So tough luck, smoking pot, or hash or anything else that gets you stoned and goofy just isn't benificial.

[TigersEye]

"100 MPG Carburetor; Government Hides Plans"

Was that your job in the old days?

[TigersEye]

So tough luck, smoking pot, or hash or anything else that gets you stoned and goofy just isn't benificial.

Maybe not for you! Some people are beyond help.

[Wolfie]

Ping.

[Glenn]

do a lot of lab tests get cancer? should we have senate hearings?

[PaxMacian]

"And don't jump to the conclusion that smoking hash will cure cancer either. Read carefully, She synthesized compounds from hashish. So tough luck, smoking pot, or hash or anything else that gets you stoned and goofy just isn't benificial."

Things need not be synthesized by corporate entities seeking
profits in order for them to be beneficial. Perhaps some careful reading will help you see the light.

Romans 14:2
One believeth that he may eat all things:
another, who is weak, eateth herbs.

See,only a fool believes he may eat all things
because he will soon find himself dead.
However if one is in ill health and weak then
provided one possesses the proper wisdom
the required assistance may be attained from herbs.
This is a simple truth verified by scripture.

Ro 14:22 Hast thou faith? Have it to thyself before God. Blessed is he that condemneth not himself in that which he alloweth

When you are screaming from the agony of pain remember to refuse the morphine as it might make you 'stoned or goofy.'

"...rightful liberty is unobstructed action according to our own will within limits drawn around us by the equal rights of others. I do not add ‘within the limits of the law,’ because law is often but the tyrant’s will, and always so when it violates the right of an individual." - Thomas Jefferson


Matthew 5:7
Blessed are the merciful: for they shall obtain mercy.

God's wrath is certain to be unleashed upon the merciless.
The SCOTUS has shown no mercy to sick and dying in order to
uphold a domination which is not supported by the Constitution
and is in direct contradiction of the word and will of God.

GOD MADE HERB
GOD SAW THAT IT WAS GOOD
GOD GAVE IT TO MAN

Genesis 1:11
Then God said, "Let the earth bring forth grass, the herb that yields seed, and the fruit tree that yields fruit according to its kind, whose seed is in itself, on the earth"; and it was so.

Genesis 1:12
And the earth brought forth grass, the herb that yields seed according to its kind, and the tree that yields fruit, whose seed is in itself according to its kind. And God saw that it was good.

Genesis 1:29
And God said, "See, I have given you every herb that yields seed which is on the face of all the earth, and every tree whose fruit yields seed; to you it shall be for food.

[headsonpikes]

Your repeated posting of Bible passages, and your fellow drug-pushers quoting of the Constitution and the Declaration of Independence on these WOD threads, only serves to prove that you are oldthinkers, not having learned to accept the evolving judgment of your betters. Once police techniques have become more sophisticated and invasive, you can rest assured that you and your reactionary cohorts will be hunted down like dogs and liquidated.

/woddie voice

[vin-one]

you had me scared for a second.....

[headsonpikes]

Never fear....

[philman_36]

I just can't wait until the crow pie eating begins. I'm gonna serve some really big pieces. It's coming, and soon.

[dcwusmc]

bump to truth and logic, the worst weapons in the world to use against the WODDIES... Not to mention the research referenced in the article and the link provided later.

[philman_36]

As more and more of this research is undertaken and the benefits of this herb come out it is understandable why our government puts so many barriers in the way of domestic researchers.
They don't want anyone to know they've got egg on their face. They're going to have to look in a mirror and scrape it off sooner or later and I recommend sooner rather than later so they can save some face.
The KUDOS could've gone to an American, but noooooo...research is blocked and others get the glory.
She deserves all of the rewards and glory she so justly earned. I just wish it would've been an American who made such a beneficial discovery.
Instead of such productive research our researchers are studying how to get a man's penis hard and make it stay hard longer! What a joke that has been played on us.