I do not understand why Duesberg cannot let the AIDS denialist theory go. I suspect it is because of his key role in retroviral research -- perhaps he cannot believe a retrovirus can do this kind of damage. It certainly can: It is of course unethical to prove HIV is the cause of AIDS by injecting a healthy volunteer with the virus. But very similar viruses cause similar diseases in apes and cats, and this has been shown by doing the obvious experiments.
AIDS denialists need to consider what they are doing: Duesberg is asserting that antiviral medicines are part of the cause of AIDS. Given the strong evidence that these medicines are extending lives, it is terrible to suggest to patients to not take these. I remember vividly what happened in the mid 1990s, when the protease inhibitors first appears: people started to talk about the Lazarus effect -- desperately sick people staged dramatic recoveries. I myself have met people who have had this happen.
Please do not stake your own health on the medical equivalent of UFOs or Bigfoot. You can find highly credentialed scientists who advance those theories too.
How?
I have never seen this shown. In fact I've never seen a reasonable hypothesis put forward for a mechanism of action. On the other hand, Duesberg argues persuasively from facts to show that HIV does no such damage, and cannot do such damage.