There are. Don't worry about that. There are several super-major problems in science, especially in the past couple of decades, that have arisen and that will fall to some one of the major thinkers when something clicks. It won't be a simple matter of putting two and two together--that is not genius. It will be classic, bank on it.
IMHO, the methological naturalism mindset is what causes tunnel-vision and prevents great leaps of progress.