Pathology of fatal human infection associated with avian influenza A H5N1 virus.
Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.
Eighteen cases of human influenza A H5N1 infection were identified in Hong Kong from May to December 1997. Two of the six fatal cases had undergone a full post-mortem which showed reactive hemophagocytic syndrome as the most prominent feature.
Other findings included
organizing diffuse alveolar damage with interstitial fibrosis,
extensive hepatic central lobular necrosis,
acute renal tubular necrosis and
lymphoid depletion.
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