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To: Kelly_2000
This is also much longer than an VHF outbreak should have lasted.

Yep.

We seem to have been through far more generations in this outbreak than in the past, and still no sign of genetic instability/burnout. Why not??

I also have questions about the blood tests used to confirm Marburg in this outbreak. We are having a high number of cases that fit the Marburg clinical profile, but the lab tests come back negative. If the lab tests are screening for antibodies produced by previous variants of Marburg, and this one is slightly different, would that explain the high number of negative test results?

It would seem some research is in order. A start might be genetic comparison between this variant of Marburg and past versions.

52 posted on 05/04/2005 12:07:40 PM PDT by EternalHope (Boycott everything French forever. Including their vassal nations.)
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To: EternalHope; Battle Axe
It would seem some research is in order. A start might be genetic comparison between this variant of Marburg and past versions.

That was what Battle Axe was getting at a few days ago. Also wanted to know if the genetic signature could help reveal the origin...

66 posted on 05/04/2005 1:59:46 PM PDT by Judith Anne (Thank you St. Jude for favors granted.)
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To: EternalHope
"We seem to have been through far more generations in this outbreak than in the past, and still no sign of genetic instability/burnout. Why not??"

We have no way of knowing unless we find someone who is directly involved in the research.I had that door firmly closed in my face yesterday.By know there should be a marked difference in the index case and subsequent cases in terms of symptoma, mortality rate and virulence. Virus are supposed to get less virulent by generation in any given outbreak NOT the reverse.

209 posted on 05/06/2005 7:30:17 AM PDT by Kelly_2000
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