Vocabulary Time-Out!
A-Girl, before I get too lost, please let me know what you mean when you use the word "Cosmology" in this context, because I don't think you're talking about the Big Bang, etc. I'm well aware that in traditional philosophy, the term "metaphysics" means the nature of reality, and it's regarded as being prior to epistemology. And not too long ago you said, to much praise by me, that most of the arguments around here are actually about the nature of reality -- which I took to be a statement about the primary role of metaphysics. But now "Cosmology" is appearing in your posts, and I'm confused. (I'm often confused, but I'm getting used to it.) So help out an old freeper.
Here we are back to the "edges" in our exchange of metaphors. I see no edges - no boundaries - no seams - to our seeking and thus would never paste "there be dragons" anywhere on the sphere to keep people from "going there".
The boundary-less structure is "all that there is" and thus Cosmology is the background sphere on which our body of knowledge should be drawn. The context is what gives the knowledge meaning.
Evidently, in your view the quest for knowledge is "tiled" into subject areas - so if one is investigating biological evolution, abiogenesis is over the edge, ditto for fields (physics) and so on. Cosmology would be another tile (or sheet of paper with its own edges) in your view. And on each edge, there would be the warning "there be dragons".
I believe the tiled concept (or compartmentalization) is a false image of both reality and knowledge and thus cannot help us to derive meaning from it.
Without that context, our body of knowledge lacks meaning.