[politicket]

Depends on what you mean by ultimate knowledge. I'm not sure what the phrase means.

It means "What do you use as a baseline in your life?" (Or does your baseline change each morning when you wake up?).

Is there anything that is steadfast and never changing in your life that you can grasp hold of as an anchor?

[Modernman]

Is there anything that is steadfast and never changing in your life that you can grasp hold of as an anchor?

My life is pretty stable as it is. I don't really have a problem with an everchanging reality.

So, I don't think your question really applies to me.