I haven't seen a pop stopper yet that's 100% effective. Firefox does a pretty good job though.
Try Admuncher. I highly recommend it. It's got a 30 day free trial. It also stops a number of malicious scripts, has a built in proxy randomizer. It's layer 3 so it's sitting right on top of the IP stack which means you don't have to change anything. Install and you're done. Well worth it. Oh and it blocks EVERYTHING.