I've got an 86 F-250 with 6.9 I think, 96 F-250 with the Power Stroke and a 99 F-350 Dump, the best gas milage is the 86 about 20 mpg if you keep it under 55. The 96 gets about 15-18 and the 99 F-350 gets about 12 but it is alot heavier. Now I will say that cars with diesels get much better milage and your F-250 is probably the new version and I hear they get better milage than any of mine.