[corkoman]

Very good article. The withdrawal of Vioxx and Celeb are forcing all new drugs to be compared with the opiodes. Other than the dependancy issue and constipation they are remarkably well-tolerated for chronic use over decades. Being compared to opiates is unfair - with their high safety profile any new drug is going to have to jump through hoops of fire to get approved.

Pain is nature's fire alarm but the Maker didnt give us a very good way to turn that alarm klaxon off.

[rdcorso]

I learned a good bit of advice right before I was supposed to start Vioxx that caused me not to take it.The article I read said you should never take a new medication that hasn't been on the market for less than seven years unless it's a life or death decision.The reason for this is the researches are just getting the information of the long term side affects at the six or seven year mark.I would also stay away from the drugs that the companies can't explain how they work.There are quite a few like that on the market and I think Celebrex is one of them.