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To: Main Street
I hope someday they can cure neuroblastoma. And other cancers that kill kids. There is nothing worse than watching a little one die like that. Nothing.
44 posted on
01/21/2005 4:57:13 PM PST by
isthisnickcool
(What do they do in the mosque on days when the guys in the front row have gas?)
To: Main Street
>>``This is very serious and the name was serendipitous, pure serendipity,''<<
If they wanted it named after a cartoon character, they could've named it Serendipity Dawg.
Seriesly, I hope this is true.
To: Main Street; Nightshift
Wow, now to make it so that it doesn't cost an arm and a leg to find out if you have that gene.
47 posted on
01/21/2005 4:57:48 PM PST by
tutstar
( <{{--->< http://ripe4change.4-all.org Violations of Florida Statutes ongoing!)
To: Main Street
Sounds like we are getting closer to the cure.
To: Main Street
Great. Now not only will I not give up smoking but I want a refund on the sin tax the government has been screwing me out of.
To: Main Street
52 posted on
01/21/2005 5:00:41 PM PST by
nicmarlo
To: Main Street
Thanks very much for posting this fascinating article.
I wonder, though, if I'm the only one who noticed the two names, Dr. Carlos Cardon-Cardo, and Dr. Pier Paolo Pandolfi...I honestly thought it was a joke, at first...;-D
59 posted on
01/21/2005 5:03:27 PM PST by
Judith Anne
(Thank you St. Jude for favors granted.)
To: Main Street
Wow! Another major breakthrough...I believe this is Major Breakthrough No. 1006. With the usual "scientists believe" and "apparently" contained in the post, I predict, sadly, that this breakthrough will go nowhere.
61 posted on
01/21/2005 5:04:51 PM PST by
iching1
To: Main Street
healthy skepticism, but a big WOW is waiting to be let out
69 posted on
01/21/2005 5:21:45 PM PST by
unspun
(unspun.info | Did U work your precinct, churchmembers, etc. for good votes?)
To: Main Street
This article sounded like something from The Onion or an April Fool's Day joke. The names just didn't ring true:
Dr. Carlos Cardon-Cardo
Dr. Pier Paolo Pandolfi
Pokemon
So I went looking for the actual article, and found it. Here's the "abstract" of the article:
Role of the proto-oncogene Pokemon in cellular transformation and ARF repression
TAKAHIRO MAEDA1,2, ROBIN M. HOBBS1,2, TAHA MERGHOUB1,2, ILHEM GUERNAH1,2, ARTHUR ZELENT3, CARLOS CORDON-CARDO2, JULIE TERUYA-FELDSTEIN2 & PIER PAOLO PANDOLFI1,2
1 Cancer Biology and Genetics Program,
2 Department of Pathology, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
3 Leukemia Research Fund Center at the Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK
Correspondence and requests for materials should be addressed to P.P.P. (p-pandolfi@ski.mskcc.org).
Aberrant transcriptional repression through chromatin remodelling and histone deacetylation has been postulated to represent a driving force underlying tumorigenesis because histone deacetylase inhibitors have been found to be effective in cancer treatment. However, the molecular mechanisms by which transcriptional derepression would be linked to tumour suppression are poorly understood. Here we identify the transcriptional repressor Pokemon (encoded by the Zbtb7 gene) as a critical factor in oncogenesis. Mouse embryonic fibroblasts lacking Zbtb7 are completely refractory to oncogene-mediated cellular transformation. Conversely, Pokemon overexpression leads to overt oncogenic transformation both in vitro and in vivo in transgenic mice. Pokemon can specifically repress the transcription of the tumour suppressor gene ARF through direct binding. We find that Pokemon is aberrantly overexpressed in human cancers and that its expression levels predict biological behaviour and clinical outcome. Pokemon's critical role in cellular transformation makes it an attractive target for therapeutic intervention.
Link (just click on "Cancel" when it tries to load the "PAF" files)
I'm still not sure if it's a hoax or not!
To: neverdem
81 posted on
01/21/2005 5:36:52 PM PST by
Nov3
("This is the best election night in history." --DNC chair Terry McAuliffe Nov. 2,2004 8p.m.)
To: Main Street
Dr. Carlos Cardon-Cardo and Dr. Pier Paolo Pandolfi. Who named these gentlemen; Amalgamated Alliteration?
To: Main Street
If it weren't for the Theory of Evolution we would never have gotten this far.
To: Main Street
Does anyone have a picture of Master Gene?
108 posted on
01/21/2005 11:26:29 PM PST by
expatguy
(http://laotze.blogspot.com/)
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