It's got a cargo capacity of over 150 tons, a whole lot more than the 747. Fedex would be crazy not to be right there smack in the middle of it.
Many jumbojets land at Anchorage and Fairbanks to refuel. None carry passengers. Some go over at 5 miles high 5 minutes apart, some headed north and some headed west. No passengers. These are freighters. If this super guppy has the range it would be a tremendous intercontinental freighter.