[bruinbirdman]

"If a large enough dose of TCDD could be absorbed through the skin, it would cause the same symptoms as ingested TCDD--the effect is systemic, not topical."

Operative words, "large enough dose". What is a "large enough dose?"

yitbos

[Vn_survivor_67-68]

What is a "large enough dose?"

That is contingent on whether you are long or short on Ah, the receptor.

[exDemMom]

Operative words, "large enough dose". What is a "large enough dose?"

The short answer is, we don't really know. The dose would be several micrograms of TCDD per kilogram body weight (ug/kg), and there is reason to think, based on species homology of the dioxin receptor (the AhR), that we are somewhere between guinea pigs (lethal dose 50(LD50) is 0.6-2 ug/kg) and hamsters (LD50 = 1000-5000 ug/kg) in susceptibility. We don't know the human LD50.