Which why anti-spyware software is NOT enough to prevent an infection. You must lock down Internet Explorer with IE Spyad and get a HOSTS file that prevents Windows from ever connecting to high-risk sites on the web and make it read only so scumware can't change it.
Here's what I run:
ZoneAlarm Pro
McAfee Internet Security Suite (except Firewall)
AdSubtract Pro (I like it's pop-up control better)
AdAware Pro with AdWatch
Backup MyPC (for nightly incremental backups)
I still got infected by CoolWebSearch.
Thing that bugs me about all of this is that it seems like there is a cottage industry of spyware/adware blockers thriving on this problem, instead of legislation to make the unauthorized theft of the use of my computer a crime.
-PJ