There is another kind of "manufacturing" which is liable to come up anyway, so I'll raise it here - that is the manufacturing of life in a test tube, e.g. the polio virus.
The virus was indeed alive [Shannon and/or Bauer] - the reason we know it was artificially constructed is that we knew the origins of it. However, it was constructed from other biological material, whose origins are not known, i.e. they occur in "nature."
Likewise, tinkering with living creatures through altering DNA, cloning, massive transplants and the ilk does not diminish the fact that the creature is alive before (and often) after the tinkering.