Like an amphetamine the size of a golf ball. Recently I read an article on sleep that talked about a drug that keeps you awake without the speed-like side effects.
22,859 / 70 = 326.56 mph. Probably the reason for the jet, though a turboprop would be more fuel efficient.
Modafinal. It is prescribed for narcolepsy. Gulf War I pilots used it. Modafinal is a controlled substance, but it predecessor, Adrafinal is not. Adrafinal requires liver enzyme monitoring if used regularly. You can read more here if curious.