Did you ever receive sulfasalazine or mesalamine treatment??
Sulfasalazine just about killed me in 1990. It attacked my bone marrow and gave me an AIDS-like condition, agranulocytosis, a lack of certain kinds of white cells.
They told me I'd had a very rare (but already known) reaction. All kinds of opportunistic infections popped up all at once over a period of a few days. Fever, then chills. Halitosis (from painful gingivitis) to kill a horse. I staggered into the emergency room with a real sense that I was dying. They bombed me with antibiotics and took me off the sulfasalazine, which I had continued taking right up to that point.
You have to watch those anti-inflammitants. It's not nice to fool Mother Nature or mess too much with your immune system.