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To: Pharmboy
You are technically correct. The drug was Baycol, it wasn't banned. The manufacturer, Bayer, withdrew it from the market after ~ 100 violent deaths.

The irony is that from what I read finding a source for my claim (God, I love FR!) it seems that low cholesterol, regardless of cause, is associated with violent death.

IOW, Baycol was a victim of it's own success!

Thanks for putting me through the pain of the search. Ya learn something every day.
47 posted on 08/16/2004 1:13:10 PM PDT by null and void (Want to live in a socialist state now? Vote (D). Want to live in a socialist state soon? Vote (R)...)
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To: null and void

This is why Baycol was removed:

BAYER VOLUNTARILY WITHDRAWS BAYCOL

FDA today announced that Bayer Pharmaceutical Division is voluntarily withdrawing Baycol (cerivastatin) from the U.S. market because of reports of sometimes fatal rhabdomyolysis, a severe muscle adverse reaction from this cholesterol-lowering (lipid-lowering) product. The FDA agrees with and supports this decision.

Baycol (cerivastatin), which was initially approved in the U.S. in 1997, is a member of a class of cholesterol lowering drugs that are commonly referred to as "statins." Statins lower cholesterol levels by blocking a specific enzyme in the body that is involved in the synthesis of cholesterol. While all statins have been associated with very rare reports of rhabdomyolysis, cases of fatal rhabdomyolysis in association with the use of Baycol have been reported significantly more frequently than for other approved statins.

Fatal rhabdomyolysis reports with Baycol have been reported most frequently when used at higher doses, when used in elderly patients, and particularly, when used in combination with gemfibrozil (LOPID and generics), another lipid lowering drug. FDA has received reports of 31 U.S. deaths due to severe rhabdomyolysis associated with use of Baycol, 12 of which involved concomitant gemfibrozil use.

Rhabdomyolysis is a condition that results in muscle cell breakdown and release of the contents of muscle cells into the bloodstream. Symptoms of rhabdomyolysis include muscle pain, weakness, tenderness, malaise, fever, dark urine, nausea, and vomiting. The pain may involve specific groups of muscles or may be generalized throughout the body.

Most frequently the involved muscle groups are the calves and lower back; however, some patients report no symptoms of muscle injury. In rare cases the muscle injury is so severe that patients develop renal failure and other organ failure, which can be fatal.

Bayer Pharmaceutical Division has announced plans to withdraw Baycol to the pharmacy level. Pharmacies will be instructed to return the product to the manufacturer for a refund.

Patients who are taking Baycol should consult with their physicians about switching to alternate medications to control their cholesterol levels. Patients taking Baycol who are experiencing muscle pain or are also taking gemfibrozil should discontinue Baycol immediately and consult their physician.

There are five other statins available in the U.S. that may be considered as alternatives to Baycol. They are: lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), fluvastatin (Lescol), and atorvastatin (Lipitor).



48 posted on 08/16/2004 1:18:07 PM PDT by Pharmboy (History's greatest agent for freedom: The US Armed Forces)
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To: null and void

As far as your other point, it was total deaths that were up in the trials where cholesterol was lowered significantly. Some of these were due to cancer, some suicide and some were due to accidental deaths.


50 posted on 08/16/2004 1:19:45 PM PDT by Pharmboy (History's greatest agent for freedom: The US Armed Forces)
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To: null and void
The irony is that from what I read finding a source for my claim (God, I love FR!) it seems that low cholesterol, regardless of cause, is associated with violent death.

Now THAT is interesting. Care to share your link to info on that?

54 posted on 08/16/2004 10:02:17 PM PDT by Netizen (Abortion is not a choice -- it's murder. The only 'choice' is which method of birth control to use.)
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