About 20 miles northwest of Ft. Myers, at the head of Charlotte Harbor (the big bay on the West Coast south of Tampa Bay). On the northern side of the Peace River.
In terms of a West Coast strike anywhere north of Naples or south of Crystal River, this is probably the best place they would choose. It'll head inland and rain out over some pretty low-population areas. Sanibel and Captiva could get smacked, though.
We used to own 3 lots near Captiva (Cayo Costa?) sight unseen, thanks to an uncle that was a real estate speculator on Sanibel....I'm kinda glad the state of Florida made us (pretty much) sell it to them. They tried to steal them for a couple of years, but finally came around with a few thousand bucks.