Maadi-Griffin used to make a pistol chambered for the .50 BMG before they got rail-roaded by the Feds. Supposedly, the recoil really wasn't that bad.
I'd like to have the new smith in 45 LC. In fact, if they really want to get me to slap down a credit card they should make the old Smith model 58 chambered to fire 45acp in moon clips.
Now that would be a dandy CCW gun I think.