...and Clean!
I live in Florida and if one is handled, I always wipe the outside with oil to keep it from rusting. Also keep a coat of any good oil on all of them to prevent rusting.
A .22 will shoot far more than 100 rounds before cleaning but they are a little bit dirty and need cleaning more than most, especially .22 auto's.
Most centerfires will shoot a long time before they really need to be cleaned. The exceptions are if you are shooting for extreme accuracy, and of course any kind of corrosive primers, or if you use the guns in a bad environment such as dust or salt water.
When I do clean them I really clean them.