In a federal election, the question is, "If a state finds that these CFR laws violate free speech and the state allows issue ads (say in a local newspaper) within 30 days of a federal election, aren't they violating the Supremacy Clause?
No. It wouldn't be the state's call to allow or even to disallow issue ads. States aren't required to enforce federal laws. If people run the ads, the feds will have to bust them.