Why did the War on Alcohol require a constitutional amendment, while the War on Some of the Other Drugs did not?
Because the modern way to trashing the Constitution is incrementalism.
Because the New Deal opened the door to government unlimited by the Constitution. There are no rules now.
Because today's prohibitionists are one-worlders and steeped in their methods.
Heroin and Cocaine are not grown in the US. The original laws banned their importation.
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It took a Constitutional amendment to change the status of alcohol from legal to illegal.
Drugs were never legal,