Hard to predict anything with this Court, but I would guess a 5-4 against the feds.
Justice Thomas has said the "substantial effects" test of the Commerce Clause is not correct and that at the very least it needs reexamining.
What is your rationale for thinking USSC will rule against the feds?
It's demonstrated liberal tendency, medically and legally. In the medical sense, I believe it's right. From a practical, legal perpsective, after blithely making their ruling in Lawrence v. Texas tacitly endorsing the homosexual lifestyle, are they now supposed to deny the drug that alleviates "Slim's Disease", i.e. AIDS, as well as the nausea that accompanies chemotherapy when patients can't tolerate pills, not to mention certain patients with chronic pain, multiple sclerosis or glaucoma?