The first, maybe. As for the second, I'll defer to the writings of James Madison (the author of the clause) on the subject:
1. The meaning of the Phrase "to regulate trade" must be sought in the general use of it, in other words in the objects to which the power was generally understood to be applicable, when the Phrase was inserted in the Constn.
2. The power has been understood and used by all commercial & manufacturing Nations as embracing the object of encouraging manufactures. It is believed that not a single exception can be named.
James Madison to Joseph C. Cabell
18 Sept. 1828
If it is conceeded that I am not allowed to own a 50mm cannon, then the second amendment does not protect my right to own any specific type of arm. The second amendment is therefore satisfied as long as, after all reasonable restrictions have been placed upon me, I am reasonably left with a weapon sufficient to protect my life, my family and my property.
I would think that a shotgun would be more than sufficient for such a task and that there is therefore no constitutional necessity or right for me to own a handgun or a semi-automatic projectile emitting armament of any kind.