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I have a Beowulf 50 upper to use on my various AR lowers and a Desert Eagle in 50 AE. I would not use eithe one for home defense unless I was being attacked by a herd of elephants. Besides the fact that they cost $3 a round to shoot, they are more suited to large or hard targets like bear or boar.

In my opinion the best inside home defense weapon is a 12 ga shotgun with a short barrel loaded with #1 shot. Around town I pack an Officer length 45ACP 1911. I have a large assortment of weapons from .17 HRM Revolver to a Barret 50BMG and a 75 caliber Brown Bess Musket. They are all fun to shoot, but there are only a few that I "train" with and the shotgun and the 45 are the ones I trust most.

Bottom line is the most effective round is the one you use, the one you are competent with.