Personally, I prefer the 458 Winchester, a dangerous game caliber that will kill anything from elephants on down.
Yes, and in the course of home defense it is as useless as a BB-gun if you miss the shot. Right? My thought is that it's better to quickly get rounds into your target and at least disorient it enough to get closer and finish-off properly. Single-shot/single-round arms (i.e. most rifles) aren't as immediately effective as a 22 pistol where you can quickly squeeze-off several rounds into your target to drop it, and then take care of the niceties.
Wouldn't want to live downrange in your neighborhood.