Anyuone who loads spyware on their machine has only themself to blame. Since pop-ups are so easy to block, anyone who gets them must want them.
Well, I sort of agree, but...these spyware companies are unethical in their approach. They trick people into installing their software, and then they do really rotten crap, like putting bogus entries in the hosts file, in order to keep the victim from being able to get to websites that offer decontamination software.
Spyware can come in on regular websites, not just popups.