Loose (verb) means to loosen, untie, let loose, release from restraints, let fly (as an arrow).
Lose means to misplace, suffer loss, fail to keep control, be defeated, and so on. In this case, I presume Nancy Pelosi lost her mind and her composure in one great spasm. She shines at that.
A lot(alot) of posters interchange looser and loser purposely as an inside joke. However, many don't actually know the difference. It's the same with to and too, there, their and they're, where and were(that one is baffling).
It's always been like that, especially among the engineer types. They know incredibly technical and difficult processes but they never learned any grammar.
You have been on FR long enough to know that lose/loose is not always a mistake. This is hugh & vey series.
OK Shower time for me. heh
I think her problem is she loosed (not a form of the word until now although FR spellcheck thinks it is :>) her mind.
Big mistake, she should constrain it.