Excuse me, but as a society, "we" (the Founders) decided that the federal government staying the hell out of intrastate business was the best way, overall, to prevent or minimize the harm caused by busybodies. When you want to repeal the IC clause, then do so and the FDA may be given jursidiction there. Until then--with the votes to back it up, you cannot maintain that as a society, we decided that on an intrastate basis.
Food and drugs are interstate business, not intrastate, and the Founders specifically gave Congress the right to regulate that commerce.
"to prevent or minimize the harm caused by busybodies"
The harm caused by busybodies? What's that? How about the harm caused by manufacturers?
"In 1937, a Tennessee drug company marketed a form of the new sulfa wonder drug that would appeal to pediatric patients, Elixir Sulfanilamide. However, the solvent in this untested product was a highly toxic chemical analogue of antifreeze; over 100 people died, many of whom were children."
Busybodies, my a$$.