Any antibiotic, by any mechanism. There's enough of a range of possibilities in the proteome that something, by some mechanism, will allow differential survival of part of the population, and that's all you need.
Which genes and why? What are the functions of those genes that you are predicting and why are you predicting them in particular?
You want more prediction? OK. The ribosomal proteins, which code for the organelle which does protein translation, will have a very small number of differences with humans; possibly even zero. Essential respiratory enzymes will be almost as conserved. I expect limited but important differences in some developmental genes; particularly those for brain development. Non-coding regions of the genome will have a much higher rate of mutation.
I am very glad you are retreating into the genetic science part of biology.
There is no retreat. The science of evolution is now centered in population genetics and molecular biology. If you had gotten any closer to the literature than 'Science News' you'd know that.