[MHGinTN]

An excellent diuretic that had a 'potassium sparing' component (aldactone, a hormone blocking agent that reduced potassium excretion via adrenal gland function). Sk had a new drug they were trying to position for direct competition with Aldactizide; SK 'found' a willing FDA person to place into public record dubious findings of the potassium sparing component causing cancer in Charles River Rats when given at doses 1000 times daily dosing. The SK drug shot to the top of the sales charts immediately and Aldactizide bottomed out. (Nice pill, with a peppermint scent, Aldactizide; excellent diuretic effect to lower BP without potassium wasting side effects) The FDA hitman received a nice position with SK a year later, when he left the FDA.

[Nov3]

Thanks for the info. Sounds like the cyclamate story.