Yep. I'll never forget what my mother said from the hospital bed after finding out that she needed a quintuple bypass. She always took good care of herself, saw doctors regularly, didn't smoke, and only drank lightly at social events ... basically she did everything right. She pointed to my dad at the end of her bed and said, "I should have smoked and drank all my life, for all the good it did me". My dad was a smoker, poker player, and drinker.
Unfortunately, my mom did not survive the bypass surgery. Undetected fatty deposits in her heart walls ruptured about 12 hrs after surgery. She was 64. Using the genealogy tools on the internet, I looked back through her family's history and found that most of them died between 55 and 65. It was genetics.