I'm going to attempt to shop it as adult literary fiction and avoid the SF genre. The SF aspect will be as an adjunct to the plot, rather than being the plot. Kind of a civilized (and coherent :) "Slaughterhouse Five" (but with an entirely different storyline; I just used that as an example of an adult literary fiction work with an SF element that avoided the SF genre).
OTOH, one of my former editors is working on a straight SF novel (in the genre) and is pretty confident he can make a go of it. Who knows? He may succeed, and I may flop.