There's not all that much a difference between .357 and +P+ 38 Special.
Most importantly, with proper training, ANYONE can handle ANY load! It's a matter of familiarity, training, and not getting into any bad habbits. A petite, young lady friend of mine learned to handle my "fun" .44Mag loads... 200gr JHP at about 1800fps! Nice, big fireball comes out of the barrel! And she is perfectly comfortable with the load, although the Ruger Redhawk it's fired from is a bit big for her.
Mark