There are obsessive/compulsive personality disorders which manifest themselves in harmful behavior, like abusing alcohol, drugs, sex, other people, etc.
But it is impossible for human beings to be hard-wired genetically to become alcoholics because alcohol is not found in the environment naturally. It is man-made, and thus cannot be something the human gene code recognizes instinctually as positive or negative.
Not so fast. Many babies, unfortunately, are born addicted to drugs and must undergo long, horrible withdrawals in the hospital before going home. The hospital slowly weens them off the the drug, often times it takes a month or so. It's not much of a stretch to reason that if this baby should experiment with that drug in later years that the addiction would be triggered, or re-ignited. Same thing probably holds true with alcohol, which is just a the drug ether in liquid form. Alcoholism seems very much to be a 'family disease', for lack of a better term.