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To: Right Wing Professor; betty boop; Phaedrus
Thank you for your reply!

Whatever. In the past I've very politely hinted this stuff is poppycock. Since it keeps getting reposted, and is now being used to attack evolution, I've decided to call it as it is. Deal with it as you wish.

Would you kindly show me where I have used Yockey references to attack evolution?! I have asserted his findings in rebuttal to abiogenesis which the evolutionists on this forum have been telling me for years is not a part of the theory of evolution! Are you now saying that the theory of evolution includes abiogenesis?

Furthermore, Yockey’s work dovetails quite nicely into the research on autonomous biological self-organizing complexity. The indication is that the evolutionary process is not happenstance, that evolution is not a directionless walk after all.

That doesn’t mean evolution didn’t happen but - IMHO - it may go a long way to explain the non-mutability of regulatory control genes which leads to eyeness developing seemingly independently across phyla, the absence of new phyla since the Cambrian explosion, the relatively rapid evolution considering finite opportunity and other such anomalies.

As to the applicability of Shannon entropy to biological systems:

A general procedure for locating and analyzing protein-binding sequence motifs in nucleic acids

Abstract In the last decade, two tools, one drawn from information theory and the other from artificial neural networks, have proven particularly useful in many different areas of sequence analysis. The work presented herein indicates that these two approaches can be joined in a general fashion to produce a very powerful search engine that is capable of locating members of a given nucleic acid sequence family in either local or global sequence searches. This program can, in turn, be queried for its definition of the motif under investigation, ranking each base in context for its contribution to membership in the motif family. In principle, the method used can be applied to any binding motif, including both DNA and RNA sequence families, given sufficient family size.

Introduction Gatlin (1) first recognized that the Shannon expression for string entropy might prove useful in sequence analysis. This function is a statistical average for the distribution of possible characters at a particular position in a message. [Although it shares the form of the Gibbs–Boltzman entropy function it is independently derived and nonisomorphic with that function (2, 3).] Gatlin insightfully proposed that this function, originally developed to assay the fidelity with which strings could be transmitted in noisy communication channels, was also appropriate for the analogous transmission of string information represented in the central dogma of genetics. Schneider et al. (4) subsequently developed a redundancy index (RI), based on this function, to profile a given family of DNA-binding-site sequences. This index measured the reduction in Shannon entropy relative to the background DNA, represented in the strings of the sequences belonging to a particular motif….

On page 313 in Yockey’s book he says ”"...The Shannon entropy and the Maxwell-Boltzmann-Gibbs entropy... have nothing to do with each other". (The Second Law of Thermodynamics) Yet you insist that Yockey is wrong. I know you have impressive credentials, but so does Yockey. Here are some of his publications I googled up:

2002c. Information theory, evolution and the origin of life. Information Sciences, 141, 219-225.
2002b. More light on pioneers of electrochemistry. Nature 415, 833.
2002a. Origin Of Life On Earth and Shannon's Theory Of Communication. In: Fundamentals of Life, Gyuala Polyi and Luciano Cagliotti, editors Elsevier.
2000. Origin Of Life On Earth and Shannon's Theory Of Communication. In: Open Problems of computational molecular biology Computers & Chemistry 24 pp. 105-123.
1995. Information in bits and bytes; Reply to Lifson's review of [Yockey 1992]. BioEssays 17: 85—88
1995. Comments on "Let there be life; Thermodynamic reflections on biogenesis and evolution" by Avshalom C. Elitzur. Journal of Theoretical Biology
1992. Information Theory and Molecular Biology. Cambridge: Cambridge University Press
1981. Self-organization origin of life scenarios and information theory. Journal of Theoretical Biology
1979. Do overlapping genes violate molecular biology and the theory of evolution? Journal of Theoretical Biology 80: 21—26
1978. Can the Central Dogma be derived from information theory? Journal of Theoretical Biology 74: 149—152
1977. On the information content of cytochrome c. Journal of Theoretical Biology 67: 345—376.
1977. A calculation of the probability of spontaneous biogenesis by information theory. Journal of Theoretical Biology 67: 377—398.
1974. An application of information theory to the Central Dogma and the sequence hypothesis. Journal of Theoretical Biology 46: 369—406.
1958. A study of aging, thermal killing and radiation damage by information theory. In Yockey/Platzman/Quastler, Symposium on Information Theory in Biology, 297—316.
1958. Symposium on Information Theory in Biology. New York/London: Pergamon Press.
1956. An application of information theory to the physics of tissue damage. Radiation Research 5: 146—155

Moreover his book (Information theory and molecular biology - Cambridge University Press) is going into its second edition. Jeepers, it is even used as a textbook!

With all due respect, Right Wing Professor, I’m not about to ignore Yockey simply because you disagree with him.

725 posted on 11/26/2003 2:05:24 PM PST by Alamo-Girl
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To: Alamo-Girl; betty boop
Since it keeps getting reposted, and is now being used to attack evolution, I've decided to call it as it is.

Would you kindly show me where I have used Yockey references to attack evolution?!

The reference was not to anything you wrote, but to recent posts by betty boop, notably this one .

Furthermore, Yockey’s work dovetails quite nicely into the research on autonomous biological self-organizing complexity. The indication is that the evolutionary process is not happenstance, that evolution is not a directionless walk after all.

There is no such indication.

In page 313 in Yockey’s book he says ”"...The Shannon entropy and the Maxwell-Boltzmann-Gibbs entropy... have nothing to do with each other".

You can repost this as often as you want; it's still wrong. The Shannon entropy is simply the combinatorial entropy of a sequence; it forms part of the total entropy. The remaining part of the total entropy is the entropy of a randomly sequenced piece of DNA of the same base composition as the defined sequence.

As for the position of Information theory in the biological sciences; this appears to be a reasonable evaluation.

813 posted on 12/01/2003 7:51:15 AM PST by Right Wing Professor
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