The issue of an omniscient, all-powerful federal government was settled in 1865.
Federalism is dead.
That put federalism on life support with occasional squiggles on the brain activity chart. The plug was pulled and official death was recorded with the passing of the 17th Amendment.
Somehow Lincoln's death machine settled the issue morally and legally with 99.99% of the country.
With secession off the table forever for any state admitted to the US, states have only one hope: an amendment clarifying their rights.