Posted on 09/30/2025 6:30:54 PM PDT by nickcarraway
Per OpenEvidence:
Acetaminophen (Tylenol) is metabolized in the liver, where a small fraction is converted by cytochrome P450 enzymes to the reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI). Under normal conditions, glutathione rapidly conjugates and detoxifies NAPQI, preventing cellular injury. However, in overdose or in states of glutathione depletion, NAPQI accumulates, leading to hepatocellular damage and centrilobular necrosis.[1-2]
Glutathione depletion is the critical event in acetaminophen-induced hepatotoxicity. Even at therapeutic doses, acetaminophen can cause a measurable decrease in intracellular glutathione, particularly in susceptible populations or with prolonged use.[3-5] The risk of toxicity is increased in individuals with impaired glutathione synthesis or pre-existing low glutathione stores, such as those with malnutrition, chronic alcoholism, or genetic defects in glutathione biosynthetic pathways.[6-7]
N-acetylcysteine (NAC) is the established antidote for acetaminophen toxicity because it replenishes hepatic glutathione, thereby restoring the capacity to detoxify NAPQI and preventing further liver injury.[4][6][8] The effectiveness of NAC is greatest when administered early, but it can still provide benefit by supporting mitochondrial glutathione and energy metabolism even with delayed treatment.[8]
In summary, the relationship between acetaminophen and glutathione is that glutathione is essential for detoxifying the toxic metabolite of acetaminophen (NAPQI), and depletion of glutathione is the key event leading to acetaminophen-induced hepatotoxicity.[1-2]
Not guilty!
She's married to Donny Wahlberg who starred in Blue Bloods, and is now in a spin-off called Boston Blue. I remember seeing her on MTV when my kids watched it years ago. My oldest will be 59 this year. She's also one of the judges on The Masked Singer.
N-acetyl-p-benzoquinone imine relies on glutathione to detoxify—just as the rest of acetaminophen does. It's not separate from glutathione, from what I have read.
We stop making enough glutathione, as we age. I posted GlyNAC studies in which health gets much better (even a 15% improvement in kidney function) by adding glycine and NAC (provided cysteine). The body craves these and immediately makes glutathione everywhere it has been needed, but couldn't.
Jenny is hitting the right stuff. Rachael, is not.
N-acetyl-p-benzoquinone imine relies on glutathione to detoxify—just as the rest of acetaminophen does. It's not separate from glutathione, from what I have read.
We stop making enough glutathione, as we age. I posted GlyNAC studies in which health gets much better (even a 15% improvement in kidney function) by adding glycine and NAC (provided cysteine). The body craves these and immediately makes glutathione everywhere it has been needed, but couldn't.
Jenny is hitting the right stuff. Rachael, is not.
bkmk
Do you remember in 2021 when the government was trying to ban it and Amazon in many places stop trying to sell it. It was really hard to get our hands on.
yes; looks like strange things are happening to replies- See #10,12
Glutathione was crucial to the treatment of COVID-19.
The body naturally depletes glutathione because its main purpose is to act as a battery of electrons to feed the oxygen atoms in the blood when they lose electrons (called free radicals). When too many free radicals accumulate, the body goes into oxidative stress where the free radicals bond with water (H2O) to become H2O2, or hydrogen peroxide. Glutathione provides the missing electron to keep the oxygen atoms pure.
COVID-19 binds with the ACE2 receptors in the endothelial cells (the cells that line the inside walls of the arteries and veins) where oxygen is absorbed into the blood. The ACE2 receptors also control the body's natural production of glutathione, so when the COVID-19 virus attacked the ACE2 receptors, it stopped the natural production of glutathione.
Glutathione depletion occurred and the body would go into oxidative stress, where the hydrogen peroxide started damaging the organs. This eventually led to people being put on ventilators, until they figured out what was really going on.
Taking NAC as a supplement kept the body producing glutathione despite the blockage of the ACE2 receptors, which gave the body the time it needed to fight off the COVID-19 virus, provided that other measures were being taken to attack the virus directly (like taking zinc with quercetin).
-PJ
Bkmk
Not guilty, case dismissed. Tylenol banned. (Didn’t work in the first place - only used to prevent Reyes Syndrome.)
Lol …. Manipulated information to fit an agenda you say?
They changed the definition of vaccine so the COVID vax could actually be called a vaccine.
That pic does not do her justice lol
Tylenol has known as a liver killer for over a decade. Yet most people don’t seem to understand this.
Like you, I quit using most OTC products unless under much distress.
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