Cheap Asian Supplement Known as the ‘Brain Herb’ May Help Delay Dementia Symptoms

New York Post ^ | Nov. 26, 2024 | Tracy Swartz

[RitchieAprile]

Does not seem like a very attractive plant. Wonder how did anyone get past the aroma to consume it?

[tired&retired]

The plant doesn’t smell bad. Just the fruit.

[TexasGator]

Your first link concludes nothing!

Duh ...

Don’t just throw out links. Provide a quote that supports your position.

---

When compared with placebo or conventional medicine in individual trials, Ginkgo biboba demonstrated similar but inconsistent findings

[TexasGator]

Thanks. I did “Ginkgo”. The first article:

This study failed to show improvement in age-associated memory impairment or mild or moderate dementia in several neuropsychologic and behavior outcome measures.21 However, this study included patients with age-associated memory impairment rather than just persons with dementia, which may have limited the statistical power of its conclusions about the role of ginkgo in dementia.22

A randomized, placebo-controlled trial23 of the effectsof ginkgo in healthy, noninstitutionalized adults without dementia or other known mental deficit found no benefit from six weeks of ginkgo therapy (120 mg per day) on several standardized neuropsychologic measures of memory and learning.

[meatloaf]

I’ve taken gingko for over ten tears along with frequent 1,200 mg doses of powdered aspirin. I never had a bleeding issue.

I stopped the aspirin when a couple of doctors blew a gasket.

I took the aspirin for decades. Goodies were my aspirin of choice.

[meatloaf]

I use the American Botanical Society translated copy. It has the references.

[Drago]

The quotes you desire are in the links I provided....but if you must use FR bandwidth/database space here you go:

“Ginkgo biboba in combination with conventional medicine was superior in improving Mini-Mental State Examination (MMSE) scores at 24 weeks for patients with Alzheimer’s disease (MD 2.39, 95% CI 1.28 to 3.50, P<0.0001) and mild cognitive impairment (MD 1.90, 95% CI 1.41 to 2.39, P<0.00001), and Activity of Daily Living (ADL) scores at 24 weeks for Alzheimer’s disease (MD -3.72, 95% CI -5.68 to -1.76, P=0.0002). When compared with placebo or conventional medicine in individual trials, Ginkgo biboba demonstrated similar but inconsistent findings. Adverse events were mild.”

“Ginkgo biloba is potentially beneficial for the improvement of cognitive function, activities of daily living, and global clinical assessment in patients with mild cognitive impairment or Alzheimer’s disease. However, due to limited sample size, inconsistent findings and methodological quality of included trials, more research are warranted to confirm the effectiveness and safety of ginkgo biloba in treating mild cognitive impairment and Alzheimer’s disease.”

Twenty two- to twenty four-week treatment with Ginkgo biloba extract EGb 761® improved BPSD (except psychotic-like features) and caregiver distress caused by such symptoms.

For coronary artery disease:

“In patients with coronary artery disease (CAD), coronary blood flow is usually impaired due to imbalanced vasoactive substances such as nitric oxide (NO) and endothelin-1 (ET-1). The study was designed to test the effects of Ginkgo biloba extract (GBE) on the distal left anterior descending coronary artery (LAD) blood flow and plasma NO and ET-1 levels. Eighty CAD patients were randomly assigned to GBE (n = 42) and control (n = 38) groups. The LAD blood flow was assessed non-invasively using Doppler echocardiography at baseline and after 2 weeks. GBE treatment demonstrated a significant improvement in maximal diastolic peak velocity (MDPV), maximal systolic peak velocity (MSPV) and diastolic time velocity integral (DTVI) compared with controls (14.61 +/- 4.51% vs 0.67 +/- 2.66%, 9.03 +/- 4.81% vs 0.34 +/- 2.67% and 14.69 +/- 5.08% vs 0.68 +/- 3.00%, respectively, p < 0.01). NO was increased by 12.42% (p < 0.01), whereas ET-1 was decreased by 5.82% (p < 0.01). The NO/ET-1 ratio was increased by 19.47% (p < 0.01). A linear correlation was confirmed between the percentage change in LAD blood flow and in NO, ET-1 or NO/ET-1 ratio following GBE treatment. The results suggest that GBE treatment in CAD patients led to an increase of LAD blood flow, which might at least be related partly to the restoration of the delicate equilibrium between NO and ET-1.”

These 3 studies are apparently just a few of many of “GBE” studies available. I personally don’t take “GBE” currently, just helping out the thread.

The 3 studies that provided the quotes above:

https://pubmed.ncbi.nlm.nih.gov/26268332/
https://pubmed.ncbi.nlm.nih.gov/28931444/
https://pubmed.ncbi.nlm.nih.gov/18446847/

Here are more GBE studies: (if TG decides to read, no quotes provided for the following studies due to post excess length/FR database space saving):

https://www.sciencedirect.com/science/article/pii/S2667142523001173

https://www.sciencedirect.com/science/article/pii/S0753332222006886

https://pmc.ncbi.nlm.nih.gov/articles/PMC5758353/

https://pubmed.ncbi.nlm.nih.gov/26268332/

A 2020 review of prior GBE studies:

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.01688/full

[TexasGator]

Your first link (which you omitted):

The general methodological quality of included trials was moderate to poor.

Conclusion: However, due to limited sample size, inconsistent findings and methodological quality of included trials, more research are warranted to confirm the effectiveness and safety of ginkgo biloba in treating mild cognitive impairment and Alzheimer’s disease.

[Drago]

All the quotes/info. are in the links for your perusal...if I posted all the text from the studies we wouldn’t need the provided links now would we?

You do know that the #1 consumed drug in the work is derived from Willow tree bark don’t you? (Aspirin). Don’t be too quick to “dis” herbal/traditional meds.

https://elearning.uniroma1.it/pluginfile.php/1384573/mod_folder/content/0/Sezione%202.4/2.4.2.0.0.0.0.2017.The%20aspirin%20story%20–%20from%20willow%20to%20wonder%20drug.pdf
(no quotes, you click)

[jcon40]

I use Bacopa for keeping my memory sharp at 74 yrs young. I know people like Ghinko B but I found Bacopa to be more effective.

This link, for Bacopa Monnieri, is from Google Scholar like I had mentioned to you in a previous comment.

Notice the page contains several studies

https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Bacopa+memory&btnG=

Good luck FRiend. This is good stuff

[Drago]

Happy Thanksgiving!! Am thankful that Americans have the freedom to buy/take safe herbal supplements if desired.

Watch out, I hear that “tryptophan” can be dangerous to your alertness levels! 🦃

[TexasGator]

“Am thankful that Americans have the freedom to buy/take safe herbal supplements if desired.”

The OTC supplement sellers that you for donating to their Merry Christmas.

[Drago]

Flu season …keep your Vitamin D levels up (>50). Call it a vitamin pill not a supplement . ;-)

(Or lots of sunbathing)