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Prophylactic Study: Hydroxychloroquine no more effective than placebo in preventing COVID-19; Front-line health workers had similar infection rates whether they took a daily regimen of hydroxychloroquine or not
Eureka Alert ^ | 09/30/2020 | UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE

Posted on 09/30/2020 8:32:51 AM PDT by SeekAndFind

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To: Mom MD

Understood. My point was that such a study is pointless. But of course it was run by MD’s, so it was bound to be pointless.

There has never been a rational biochemical argument that HCQ could possibly prevent infection.

Perhaps for their next stupid MD trick, they can study whether wearing a seat belt prevents car crashes. Or whether wearing a parachute prevents aircraft mechanical failures.


61 posted on 09/30/2020 4:06:33 PM PDT by Go_Raiders (The fact is, we really don't know anything. It's all guesswork and rationalization.)
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To: Go_Raiders

1 Oct: Daily Mail: Australian scientists insist hydroxychloroquine COULD prevent people catching COVID-19 after giving the controversial drug to hundreds of health care workers
•Melbourne researchers believe hydroxychloroquine could prevent COVID-19
•Scientists are studying whether the drug works as a prophylactic for the disease
•About 230 front line healthcare workers signed up for the COVID SHIELD trial
•Studies found drug can impede replication of COVID-19 and discourage growth
By Jackson Barron
Researchers from the Walter & Eliza Hall Institute in Melbourne believe the drug could prevent people catching SARS-CoV-2 - the virus that causes COVID-19.
Hundreds of health workers in NSW and Victoria have been given the drug in the Institute’s COVID SHIELD trial in an effort to try and determine its effectiveness as a prophylactic...

COVID SHIELD co-lead investigator Marc Pelligrini said researchers were not considering the drug as a treatment, but as a preventative...

Test tube studies have found hydroxychloroquine can work to impede the replication of COVID-19 and discourage proliferation...
‘Hydroxychloroquine is a drug that is cheap and readily available, with very few side effects. If there is a chance this drug could help prevent frontline healthcare workers from getting COVID-19, I think it is important that we do a proper clinical trial to test it,’ she said...

While the Australian researchers remain hopeful hydroxychloroquine could prevent COVID-19, a U.S. study (Uni of Pennsylvania) found on Thursday the drug offers no protection...

WHY IS HYDROXY-CHLOROQUINE CONTROVERSIAL?
It was touted as a wonder drug by Donald Trump despite no evidence it could treat Covid-19...
https://www.dailymail.co.uk/news/article-8790261/Australian-scientists-insist-hydroxychloroquine-prevent-people-catching-COVID-19.html


62 posted on 09/30/2020 4:31:42 PM PDT by MAGAthon
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To: MAGAthon

They are misusing the word “preventative.”

At best, HCQ can cause an infection to become so trivial that the infectee never realizes they have been infected and never sheds enough virus to infect others.

People may mistakenly believe that constitutes “prevention” when in fact there was an underlying infection, albeit negligible.

Such an approach is a mixed blessing. The infectee will not develop immunity in such a circumstance, which delays overall community resistance to the virus. It is the rough equivalent of what New Zealand has done, creating a restricted way of life that cannot be altered until an effective vaccine is available.

This would be a viable approach to protecting the vulnerable until community resistance takes hold, but at this point the waters of opinion regarding HCQ have been so muddied that it is a non-starter in the country.


63 posted on 10/01/2020 9:25:10 AM PDT by Go_Raiders (The fact is, we really don't know anything. It's all guesswork and rationalization.)
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To: SeekAndFind

No zinc = fake study


64 posted on 10/03/2020 6:29:24 AM PDT by Chauncey Gardiner
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To: SeekAndFind

Yet another study looking to trash HCQ by excluding zinc.


65 posted on 10/03/2020 6:30:48 AM PDT by 9YearLurker
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To: SeekAndFind

Maybe too soon to rule out hydroxychloroquine; tricking the immune system

In a series of randomized controlled trials, the malaria drug hydroxychloroquine did not show a statistically significant impact on the prevention or treatment of COVID-19. But when data from five of those trials were combined, researchers found that early use of the drug by people who were not hospitalized yielded a statistically significant 24% reduction in risk of infection, hospitalization or death. “The meta-analysis pools together the studies and increases statistical power,” said Dr. Joseph Ladapo of the David Geffen School of Medicine at UCLA, coauthor of a report posted on Wednesday on medRxiv ahead of peer review. But a weakness of the meta-analysis, Ladapo acknowledged, is that infections, hospitalizations and deaths were grouped together into a “composite outcome.” Combining all those events into one big number makes it more likely researchers will find that treatment had a significant effect. Coauthor Dr. Harvey Risch of the Yale School of Public Health noted that seven nonrandomized controlled trials have also shown “statistically significant reduced risks with early outpatient use of hydroxychloroquine.” Along with the meta-analysis, he told Reuters, “This is extremely strong evidence of benefit.” (https://bit.ly/2SlHEeE)
https://news.yahoo.com/maybe-too-soon-rule-hydroxychloroquine-210456294.html


66 posted on 10/03/2020 6:38:04 AM PDT by ironman
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