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Gilead antiviral drug remdesivir flops in first trial
ft.com ^ | 04.23.2020 | FT

Posted on 04/23/2020 9:58:54 AM PDT by rxsid

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To: rxsid

Chinese Trial...Published by WHO....Accidentally...Disputing something that could help end this for once and for all....ANNNNNDDDDDD there is a shred of credibility with this because?


41 posted on 04/23/2020 10:32:27 AM PDT by gas_dr (Trial lawyers AND POLITICIANS are Endangering Every Patient in America: INCLUDING THEIR LIBERTIES)
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To: rxsid

lenzilumab may be a drug you will be hearing soon.


42 posted on 04/23/2020 10:33:29 AM PDT by Democrats hate too much
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To: rxsid
The CovidChinese have already stolen the Remdesivir formulation.

So, factor that in when you think about why Chinese puppet WHO "leaked" this.

43 posted on 04/23/2020 10:33:59 AM PDT by kiryandil (Chris Wallace: Because someone has to drive the Clown Car)
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To: rxsid

It is a slow tedious process to come up with drugs that work effectively. That’s why drug companies spend so much on research and development. With the whole world working on this problem I suspect a solution will emerge but maybe not as fast as people want.


44 posted on 04/23/2020 10:34:21 AM PDT by plain talk
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To: gas_dr
This "event" is all on the WHO
45 posted on 04/23/2020 10:34:30 AM PDT by rxsid (HOW CAN A NATURAL BORN CITIZEN'S STATUS BE "GOVERNED" BY GREAT BRITAIN? - Leo Donofrio (2009))
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To: Jeff Chandler

With the side effects of barking and begging for treats.


46 posted on 04/23/2020 10:34:38 AM PDT by Rockingham
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To: kiryandil
"...Chinese puppet WHO "leaked" this. "

Yup.

47 posted on 04/23/2020 10:35:57 AM PDT by rxsid (HOW CAN A NATURAL BORN CITIZEN'S STATUS BE "GOVERNED" BY GREAT BRITAIN? - Leo Donofrio (2009))
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To: rxsid

The link isn’t working for me.


48 posted on 04/23/2020 10:39:25 AM PDT by Rocky
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To: plain talk
"It is a slow tedious process to come up with drugs that work effectively. That’s why drug companies spend so much on research and development."

That's right.

Unfortunately, it costs a lot of money, and time, to bring a drug to market.

Everyone involved, from the support staff, to the scientists, to the medical consultants wants to earn a nice paycheck, especially those with advanced degree's.
If an auto worker can get $30/hour to install a windshield in a car, then an MD/PhD pharmaceutical scientist working on a molecular biology based cure for a scourge like ebola should be able to earn at least that, if not double or triple. It's just how the world works.

The estimated average cost to bring 1 drug to market is between $648,000,000 and $2,700,000,000. [1] [2][3]

The estimated average time ( from initial discovery to the marketplace and all the phases in between) to bring a drug to market is 10 years. [1][2][3]

Then, there is the very high percentage of failures in the process. Only an estimated 1 of every 10 drugs investigated make it to market. A 90% "failure" rate. That's lots of time and money spent on something they can never make money on. [1][2][3]

Cost is always going to be an issue with those kinds of numbers involved.


49 posted on 04/23/2020 10:41:11 AM PDT by rxsid (HOW CAN A NATURAL BORN CITIZEN'S STATUS BE "GOVERNED" BY GREAT BRITAIN? - Leo Donofrio (2009))
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To: All
Here's a link.

“We regret that the WHO prematurely posted information regarding the study, which has since been removed. The investigators in this study did not provide permission for publication of results,” a Gilead spokesperson said in a statement to CNBC.

“Furthermore, we believe the post included inappropriate characterizations of the study. Importantly, because this study was terminated early due to low enrollment, it was underpowered to enable statistically meaningful conclusions,” according to Gilead. “As such, the study results are inconclusive, though trends in the data suggest a potential benefit for remdesivir, particularly among patients treated early in disease.”

50 posted on 04/23/2020 10:47:44 AM PDT by mmichaels1970
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To: MinorityRepublican

meaning what? What’s really going on?


51 posted on 04/23/2020 10:51:13 AM PDT by spacejunkie2001
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To: Jeff Chandler

“Well that stinks. We need it as a backup for when Covid-19 selects resistance to HCQ.”

Good comment.

Good because the mechanism of the remdesivir is I be that would foster resistance.

Chloroquine not.


52 posted on 04/23/2020 10:57:55 AM PDT by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: rxsid

“Exclusive: Disappointing results revealed in draft documents published accidentally by WHO”

https://www.breitbart.com/national-security/2020/04/23/china-sends-30-million-to-w-h-o-after-u-s-freezes-funding/

China Sends $30 Million to W.H.O. After U.S. Freezes Funding

The Chinese Foreign Ministry announced on Thursday it will donate another $30 million to the World Health Organization (W.H.O.), which is under growing scrutiny from member states for its poor handling of the Wuhan coronavirus pandemic and its suspicious tendency to toe the political line from Beijing.

American taxpayers are far and away the most important funders of the W.H.O., having donated over $400 million last year, compared to China’s total of $86 million.

“China has decided to donate another $30 million in cash to the W.H.O., in addition to the previous donation of $20 million, to support the global fight against COVID-19 and strengthen developing countries’ health systems,” Foreign Ministry spokesman Geng Shuang said at a press briefing.

Geng said the donation “reflects the support and trust of the Chinese government and people for W.H.O.”


53 posted on 04/23/2020 10:58:16 AM PDT by maggief
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To: ifinnegan

Malaria has developed resistance to Chloroquine.


54 posted on 04/23/2020 11:01:42 AM PDT by Jeff Chandler (BLACK LIVES MAGA)
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To: Lurkinanloomin

“It flopped for its original purpose against Ebola as well.”

These types of drugs never work well and they’re very toxic.


55 posted on 04/23/2020 11:11:31 AM PDT by ifinnegan (Democrats kill babies and harvest their organs to sell)
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To: rxsid

If I were unscrupulous and very powerful, and were invested in a different drug or in a vaccine, I would try to undermine results from remdesevir, hydroxy, etc., that would render my product irrelevant or less valuable.


56 posted on 04/23/2020 11:29:36 AM PDT by xzins (Retired US Army chaplain. Support our troops by praying for their victory.)
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To: rxsid
I'm not going to just dump on remdesivir, it has a unique way of fooling COVID-19 into thinking that it's adenosine.

Which I believe will eventually be overcome by the virus mutating to ignore remdesivir gluing down the "A" on the amino acid keyboard.

Nonetheless, we know have a series of articles, featuring CCP STUDIES (and one really awful survey study by NIH), that attempt to destroy all existing protocols.

This is almost a bald-faced progrom to pave the way for 2 things - a Chinese miracle drug, and Gates' miracle vaccine.

57 posted on 04/23/2020 11:39:54 AM PDT by StAnDeliver (CNN's Dana B: "Show of hands: Coverage for undocumented immigrants?" ***all Democrat hands raised***)
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To: politicket

Maybe hydroxychloroquine also has direct action against the virus.


58 posted on 04/23/2020 11:43:47 AM PDT by reasonisfaith (What are the implications if the Resurrection of Christ is a true event in history?)
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To: cornfedcowboy

We desperately need an effective therapeutic.


This. I have no politics whatsoever when it comes to an effective treatment regime. None. Zip. Nada.

All things being equal I am hoping the very cheap HCQ regime is the ticket and there is solid anecdotal information about it based on what I have heard and read, but if it is an expensive new drug from a pharmaceutical company I will take it in a heartbeat.

We must have an effective treatment regime once a person is diagnosed or begins to present symptoms. If there is a prophylactic effect that is a bonus.

I am praying for HCQ, HCQ/Zinc/Z-pak, Remdesivir, and any other potential treatment.


59 posted on 04/23/2020 12:04:41 PM PDT by volunbeer (Find the truth and accept it - anything else is delusional)
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To: Jeff Chandler

“We need it as a backup for when Covid-19 selects resistance to HCQ.”

HCQ is an anti-inflammatory medication, so one of the main effects of HCQ during C-19 infection is to help suppress the massive inflammatory and cytokineover over-reaction by the body, which has nothing to do with any resistance C019 might develop to anything; in fact, if resistance was going to develop it would be resistance to actual anti-virals like remdesivir


60 posted on 04/23/2020 12:08:20 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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