It may not be a popular view, but I believe that we do need a CDC. The last few years have been political and awkward at best. However, historically the CDC has played a very important role in disease control.
If we need it, then let a constitutional amendment be passed by the states to create such authority for the federales. This ignoring the clear processes laid out in the constitution, just because... its purpose is to limit runaway government, that’s why they insist it be ignored.