The antipathy between New England and the South goes way back to before the war of Independence. They were founded by different groups from England who did not like each other even back there. This is nothing new.
New England has always favored big government. The South has always favored limited and decentralized government. I don’t think we can ever bury the hatchet so to speak. Separation would be best for all concerned. It was a mistake to try to shoehorn two mutually antagonistic regions and political cultures into one country to begin with.
This article sums it up. I often think there still would have been a War Between the States even if there had never slavery. There is just too much difference in many ways between the South and West vs. the rest. As we say down here “They hate us ‘cause they ain’t us”.