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To: bray
Finally, someone invented Pfizermectin to end Corona.

If this is indeed the same as Ivermectin, then at least some of us who can't get Ivermectin now, will be able to get this.

67 posted on 12/22/2021 11:54:19 AM PST by FreeReign
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To: FreeReign; bray

“A new rumor claims that Paxlovid, Pfizer’s Covid drug, is merely a “dressed up” ivermectin molecule with little difference other than price. The term “Pfizermectin” is even being used to emphasize this. But biochemical and pharmacokinetic data say otherwise. Here are the numbers.”

https://www.acsh.org/news/2021/12/02/how-does-pfizers-paxlovid-compare-ivermectin-15967

“Bottom line

It is abundantly clear that the “Pfizermectin” myth is just that. PF-07321332 is a potent enzymatic inhibitor of Mpro with proven efficacy in clinical trials. Ivermectin has very poor potency in this same assay. Ivermectin, if it works at all, is certainly not functioning as a protease inhibitor.
Based on in vitro studies, Ivermectin is a weak inhibitor of viral replication in cultured cells.

But the antiviral inhibition of ivermectin is weak enough that even at high or multiple doses of the drug blood concentrations do not reach its cellular assay IC50 of 2µM.

PF-07321332 is a potent inhibitor in both the enzymatic and call-based assays.

The drug reaches and remains at blood concentrations sufficient to inhibit 90% of viral replication in cells for one day and does so well below toxic levels.

These data tell us that ivermectin neither inhibits the viral protease in an enzyme-based assay nor slows the production of virus in cells while Pfizer’s drug does both. If ivermectin is proven to be an effective Covid treatment it must be acting by some yet-unknown mechanism.


90 posted on 12/22/2021 6:48:33 PM PST by Pelham (Q is short for quack )
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