Rubio said he won’t run in 2022 anyway. Since he violated his last promise in that regard and said “this time I really mean it,” I suspect he won’t. Ivanka would be a good candidate considering that the GOP doesn’t really have a high profile alternative to Rubio. You can be certain the Dems will pull out all the stops. I am guessing DeSantis will run for re-election.
Rubio should run for gov like DeWine. DeSantis goes to the senate.