I make it a point to fire at least 500 rounds of .22 a month from either a scoped 10/22 or a small 9 shot revolver I have. With the rifle I can put almost every shot inside of a half dollar at 75 yards.
I can put every shot from the pistol inside of a small paper plate at 7 yards in less than five seconds. I dont use either for my EDC obviously, but if push came to shove I know I could stop Mr. Bad Guy with that little revolver.
The .22 in your hand will beat the 9mm you left at home every single time.
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Roger that
Also 22s are almost as successful in stopping attackers with one shot.
Not from physical damage, but psychologically people don’t want to be shot by anything and retreat after being shot