For Big Game, Elk and Black Bear up here in the mountains of centra-western Idaho, I use a CT Arms, Hawkin .54 caliber with about 120 grain load. good little recoil, but it does take them down. Please forgive my spelling.
450 grn maxi ball in front of 110-120 grains of Pyrodex gets the job done! Of course it all depends on what you are hunting.