I routinely take pistols out to the 500 yard metallic silhouette range and test their trajectories and their ability to hit man sized targets. It is very doable. A 380 peters out at 400 yards, but a 45, 357, 44 mag, 40, 45 colt, all hit 500 yards no problem. I’d say 1 in 10 shots will hit a human target, and another 6 in 10 will definitely cause a human target to take cover.
It’s a lot harder with the .357, as I always had a hell of a time seeing where I was hitting. .41 Mag, .44 Mag, .45LC wasn’t a problem.
I shot a moving possum at 30 meters (Glock 17) 3 times and thought i was something. Guess not...I shot it because it was daytime and it was harassing my dog - both strange. I figured it was probably rabid.